Characterization of immunosuppressive proteins of Brugia malayi microfilariae.
Identifieur interne : 00E669 ( Main/Exploration ); précédent : 00E668; suivant : 00E670Characterization of immunosuppressive proteins of Brugia malayi microfilariae.
Auteurs : A A Wadee [États-Unis] ; A C Vickery ; W F PiessensSource :
- Acta tropica [ 0001-706X ] ; 1987.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Animaux, Brugia (immunologie), Concanavaline A, Filariose lymphatique (immunologie), Filarioses (immunologie), Gerbillinae, Humains, Interleukine-2 (biosynthèse), Microfilaria (immunologie), Protéines (immunologie), Protéines (isolement et purification), Souris, Souris de lignée C3H, Tolérance immunitaire, Électrophorèse sur gel de polyacrylamide.
- MESH :
- biosynthèse : Interleukine-2.
- immunologie : Brugia, Filariose lymphatique, Filarioses, Microfilaria, Protéines.
- isolement et purification : Protéines.
- Activation des lymphocytes, Animaux, Concanavaline A, Gerbillinae, Humains, Souris, Souris de lignée C3H, Tolérance immunitaire, Électrophorèse sur gel de polyacrylamide.
English descriptors
- KwdEn :
- Animals, Brugia (immunology), Concanavalin A, Electrophoresis, Polyacrylamide Gel, Elephantiasis, Filarial (immunology), Filariasis (immunology), Gerbillinae, Humans, Immune Tolerance, Interleukin-2 (biosynthesis), Lymphocyte Activation, Mice, Mice, Inbred C3H, Microfilariae (immunology), Proteins (immunology), Proteins (isolation & purification).
- MESH :
- chemical , biosynthesis : Interleukin-2.
- chemical , immunology : Proteins.
- chemical , isolation & purification : Proteins.
- chemical : Concanavalin A.
- immunology : Brugia, Elephantiasis, Filarial, Filariasis, Microfilariae.
- Animals, Electrophoresis, Polyacrylamide Gel, Gerbillinae, Humans, Immune Tolerance, Lymphocyte Activation, Mice, Mice, Inbred C3H.
Abstract
Inhibition of Concanavalin A-induced lymphocyte proliferation was used to monitor the partial purification and characterization of suppressor molecules from microfilariae of Brugia malayi. Suppressor activity was present in high molecular weight fractions of microfilarial extracts (Mr greater than 50 kd on SDS-PAGE) and was protease-sensitive but resisted treatment with sodium periodate, indicating that it is associated with parasite proteins. Suppressor activity was released by microfilariae cultured in vitro and could be detected in peritoneal exudates of intraperitoneally-infected jirds and in lymph and sera from athymic C3H/HeN mice with patent B. malayi infections. These findings indicate that immune unresponsiveness during patent filarial infections may result from the in vivo release by microfilariae of high molecular weight proteins that suppress host immune responses.
PubMed: 2892371
Affiliations:
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xml:lang="en">Characterization of immunosuppressive proteins of Brugia malayi microfilariae.</title><author><name sortKey="Wadee, A A" sort="Wadee, A A" uniqKey="Wadee A" first="A A" last="Wadee">A A Wadee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Tropical Public Health, Harvard School of Public Health, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Tropical Public Health, Harvard School of Public Health, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name></author><author><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name></author></analytic><series><title level="j">Acta tropica</title><idno type="ISSN">0001-706X</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brugia (immunology)</term><term>Concanavalin A</term><term>Electrophoresis, Polyacrylamide Gel</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (immunology)</term><term>Gerbillinae</term><term>Humans</term><term>Immune Tolerance</term><term>Interleukin-2 (biosynthesis)</term><term>Lymphocyte Activation</term><term>Mice</term><term>Mice, Inbred C3H</term><term>Microfilariae (immunology)</term><term>Proteins (immunology)</term><term>Proteins (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Animaux</term><term>Brugia (immunologie)</term><term>Concanavaline A</term><term>Filariose lymphatique (immunologie)</term><term>Filarioses (immunologie)</term><term>Gerbillinae</term><term>Humains</term><term>Interleukine-2 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polyacrylamide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inhibition of Concanavalin A-induced lymphocyte proliferation was used to monitor the partial purification and characterization of suppressor molecules from microfilariae of Brugia malayi. Suppressor activity was present in high molecular weight fractions of microfilarial extracts (Mr greater than 50 kd on SDS-PAGE) and was protease-sensitive but resisted treatment with sodium periodate, indicating that it is associated with parasite proteins. Suppressor activity was released by microfilariae cultured in vitro and could be detected in peritoneal exudates of intraperitoneally-infected jirds and in lymph and sera from athymic C3H/HeN mice with patent B. malayi infections. These findings indicate that immune unresponsiveness during patent filarial infections may result from the in vivo release by microfilariae of high molecular weight proteins that suppress host immune responses.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><noCountry><name sortKey="Piessens, W F" sort="Piessens, W F" uniqKey="Piessens W" first="W F" last="Piessens">W F Piessens</name><name sortKey="Vickery, A C" sort="Vickery, A C" uniqKey="Vickery A" first="A C" last="Vickery">A C Vickery</name></noCountry><country name="États-Unis"><region name="Massachusetts"><name sortKey="Wadee, A A" sort="Wadee, A A" uniqKey="Wadee A" first="A A" last="Wadee">A A Wadee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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